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My vet has looked at Sweetie and short of a muscle biopsy, we are thinking she is hypo magnesium.  I was grooming her for international endurance, but she can be very nervous at the vet checks to the point that she does not pulse down.  I have tried her on MVP magnesium,  7000mg a day, but needed 7000mg to see a difference.  It took at least a month to see improvement and two months to have a safer horse.  The low magnesium seemed to be the problem.

I am a very experienced endurance rider, 30+ years breeding and training my own horses.  Sweetie's daughter is much worse.  No difference with 7000mg a day of magnesium.  We call her Emma the dilemma.  She is 6 and energy explodes out of her face.  These are happy, healthy horses, but extremely sensitive to new surroundings and anything touching their skin when not on magnesium.  They have both been to a very quiet, understanding trainer who did wonders, but the physical problems with the muscles tremors and panic attacks very much worried my vet, who is also my friend and worried about my safety.  The magnesium almost got rid of all the muscle tremors and panic attacks are gone, but both mares are still nervous.
They are not worse in "season".  Sweetie just goes a little faster down the trail and is much hungrier at the endurance ride.
This will be Sweetie's third endurance year.  She is as nervous at home as at the ride.  She is still very insecure, even on trails we train on all the time.  She has learned to let horses pass her and pass horses.  She does not get very amped up when she is passed as she is well trained.  I do not allow any horses to be dangerous, spin and be stupid.  We step out of the situation and do some dressage work until the horses are calm.
The trainer actually sent Emma home until I could get her magnesium level figured out as she was not on it for the two months that he had her.  The trainer felt he could not do as good a job with Emma wanting to blow at any moment.  She never did as she is cooperative, but I need to figure out how to control the energy.  The trainer worked with both horses, so he knew I had a genetic issue with Emma and the low magnesium. 
 
Both horses are on a good joint supplement and vitamin supplement with probiotics.
I work in emergency medicine and it is wonderful to talk to you, as you are asking all the appropriate questions.
 
Have a good New Years!
 
Karen